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Sperm quality and subpopulation behavior.

The quality of sperm in a semen sample does not depend, as previously thought, on the individual quality of sperm samples. On the contrary, it depends on the joint action of sperm subpopulations.

 

This conclusion, which is based on a clear research premise, has been made possible by the work of researchers from the University of Valencia and the PROISER Company.

 

Sperm quality: A job of many years

The study on sperm behavior and sperm quality in different samples has been the main objective of the Department of Cell Biology, Functional and Physical Anthropology of the University of Valencia for several decades. A line of research that has been supported by the Valencian company PROISER, dedicated to the diagnosis of semen samples and which has developed revolutionary software to reveal parameters of sperm samples and give answers on sperm morphometry.

Sperm morphology is a line of study and work that is based on the correct identification of sperm involved in the reproduction function of some internal fertilization species.

An area of work in which the members of the research team of the University of Valencia raised the need to check the starting point of many of the work that had been carried out in the laboratories. Works that claimed that the success of fertilization depended on the health of a sperm and its individual ability.

However, thanks to the trials carried out by the professionals of the University of Valencia, it was possible to verify that the way sperm behave in a reproduction process is mainly due to the joint action of them and the coordination they develop with each other.

Hence the main element of work in internal in Vitro fertilization processes is no longer a single sperm, but a sample of them.

computer assisted counting. sperm quality

Sperm analysis. – CASA System

The findings of this study revolutionized the field of assisted reproduction by offering answers and solutions around male fertility with internal fertilization.

 

Reference in the field of reproduction

With this new work, which has been echoed by numerous scientific journals, a change in assisted reproduction strategy has been defined, both in its veterinary and human applications. What has made both the University of Valencia and the company PROISER a reference for the rest of the laboratories and entities that carry out their work in this field.

This new milestone adds to other PROISER findings in the same area. This private entity has been developing computer programs and applications for more than a decade that favor successful seminal analysis. In fact, it is noted as a leading company in the development of different systems of sperm analysis that in the professional field are known as “Computer Assisted Semen Analysis“. A quantification system that has full implementation today.

PROISER. sperm quality

CASA System

In this way, PROISER continues to advance and place Valencian talent at the top of the international ranking.

evaluate sperm morphology

Evaluate sperm morphology

How do you do stain to evaluate sperm morphology?

Approximately 15% of couples have infertility problems. Evaluate sperm morphology is an important parameter forsuccessful fertilization. In assisted reproduction techniques (Kuster et al., 2004) the Kruger criteria(1986) and the WHO classification are the most important. According to the Kruger criteria, the head,neck and tail of the sperm must be normal and 70% of the head must be covered by the acrosome.

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espermatozoide

Sperm quality and behavior of subpopulations.

Sperm quality and subpopulations behaviour.

The quality of the sperm from a semen sample does not depend, as was previously thought, on the individual quality of the semen, this depend the joint action of many sperm subpopulations.

espermatozoide
This conclusion, which is based on research carried out in recent decades by various research groups, has been corroborated by the joint work of researchers from the University of Valencia and the PROISER R + D, S.L.

The study on the sperm behaviour and their quality in samples of diverse species has been one of the main objectives of the research group by Dr. Carles Soler in the Departament of Celular biology, Functional Biology and Physical Anthropology of the Universitat de València for several decades. A line of research that has been linked to the approaches of I D I from the Valencian company PROISER, dedicated to the development of solutions for the diagnosis of semen samples. They have developed a revolutionary software to study the divers quantitative parameters of sperm samples.

As a result of the experience acquired, Dr. Carles Soler, as head of the University’s research group and as scientific director of PROISER, was invited to be the editor of two special issues in the prestigious journals Asian Journal of Andrology (2016) and Reproduction, Fertility and Development (2018), respectively, with morphometry and sperm kinetics.

The CASA systems (Computer Assisted Semen Analysis) developed by PROISER provides a databases for tens of thousands of sperm. The application of advanced statistical techniques of multivariate analysis (main components and cluster) from these databases have allowed to consolidate the concept of subpopulations.

Hitherto, has been thought that the behavior of sperm within an ejaculate was comparable to what happens in a marathon: many runners, in principle equivalent, competing for the goal that is the oocyte. Now, the verification mathematically coherent subpopulations points more or less organized team concept.

All of this is around about what happen the sperm in a female tract. Each spermatozoonfind many obstacules and barriers that help to select the best sperm. We can say that it is similar to chess. It would not make sense to spend the towers or even the king in the opening and the first dabbling, that’s what the pawns are for.

espermatozoideIn any case, we still do not know what the rules that the sperm through in the female genital tract. The essay by the Universitat de València and PROISER, are currently work for to find more solutions.

 

Referent in the reproduction area

In addition to the physiological conditions, these results should lead to the definition of changes in the strategies followed in assisted reproduction, both in their veterinary and human applications. This group of studies and the new perspectives that have consider turned the group of the Universitat de València and PROISER into world leaders.

This new points come in addition to other PROISER findings in the same area. It is this private company has been developing software and computer applications for more than a decade that help to do a successful seminal analysis.

In this way, PROISER continues to advance and placing Valencian talent at the top of the international ranking.