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PROISER. anonymity of donors

The Bioethics Committee asks the Government to end the anonymity of sperm and ova donors

The Assisted Reproduction Law only provides for reporting the identity of biological parents for medical reasons

 

The Spanish Bioethics Committee has asked the Government to change the law that regulates assisted reproduction treatments in Spain and to end the anonymity of ova and sperm donors. The proposal, embodied in a report that has been debated for months, aims to prioritize the “interests of children born by assisted reproductive techniques.” Although the petition is not retroactive, it would not affect children already born.

Spanish reproductive medicine not only meets the needs of the indigenous population but has also become the best international destination for fertility treatment. The quality of the treatments is one of the reasons why Spanish medical centres are chosen, but also the anonymity of donors. In several countries this has already disappeared and with it has brought a gigantic drop in the donation of gametes.

Until now, only the age and blood group of the donors were communicated to the recipients, but the bioethical organism considering another perspective that “it can only be up to the child of these techniques to decide whether or not he wants to know and to what extent”.

In Proiser we advise you to follow this link for more information.

PROISER Fertility studies

Proiser develops fertility studies in freshwater fish

Proiser together with the University of Valencia develop fertility studies in sperm samples from humans and animals, and have obtained results in freshwater fish that could be useful to protect endangered species such as salt salmon.

Proiser is the name of a Valencian company whose work is carried out in the research and development of automated systems of diagnosis and automatic semen analysis.

Its origin is located in 2004, when Dr. Carles Soler (Professor of the University of Valencia in the field of Cell Biology, Functional Biology and Physical Anthropology), and computer engineer Francisco Blasco (Computer Engineer) join to develop semen analysis systems.

Proiser‘s main product line is the ISAS (Integrated Semen Analysis System) family, composed of CASA (Compuert Assisted Semen Analysis) systems, reusable and disposable cell counting chambers, and all the tools needed to perform numerous routine andrology lab analyses. Hence this company is at the forefront of what is going on in this field of biology and the environment.
The ISAS software used by Proiser is, today, the most advanced and cutting-edge solution to perform the automatic analysis of all types of semen. In fact, it is capable of analyzing more than 2000 cells per field, and more than 80,000 sperm by analysis. A job that will allow you to evaluate sperm mobility, sperm concentration, sperm morphology and other similar characteristics at the same time.

Fertility studies. Proiser products.

Currently, Proiser has a wide range of products that allow the correct manipulation, study and analysis of semen of different animals (including humans).

In addition, it develops its own lines of research such as the one that focuses its attention on the fertility of freshwater fish.

In this context, professionals from Proiser and the University of Valencia have already published results around sperm quality studies in humans and animals; as well as the results that have been obtained in freshwater fish, made with their own technique.

Particularly relevant have been its conclusions as far as salt salmon are concerned, a very important species at a commercial level and which has come to conclude, for example, that genetic-environmental interactions can be an important factor in the reproductive competition of male individuals of this species.
To carry out this work, Proiser has used a technique of his own with which they have been able to study sperm kinetics, thus identifying the different sub-populations of sperm that exist.
This work is part of Horizon 2020’s IMPRESS-Marie Sklodowska-Curie Program. A European programme that has allowed, for example, the experimental part to have been developed at the National Conservatory of Salmon Salar in the French town of Chanteuges.
PROISER ISAS Fertility Studies

 

This line of research highlights the important contribution of the Integrated Semen Analysis System (ISAS) in the study of different parameters of semen samples such as concentration, motility, percentage of progressives or different kinetic parameters and their use for scientific advancement in areas such as clinics, humans and veterinarians, scientific research, toxicology or livestock production among others.

How do you do stain to evaluate sperm morphology?

For the correct visualization of a sperm sample it is important to know how to stain to evaluate sperm morphology. Approximately 15% of couples have infertility problems. Morphology is an important parameter for successful fertilization.

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Combined effect of counting chamber and diluent on sperm kinematics

The evaluation of sperm motion is crucial for processing of seminal doses for artificial insemination.

The evaluation of sperm The evaluation of sperm motion is crucial for processing of seminal doses for artificial insemination. Here, the combined effect of the type and capture area of three counting chambers, together with the type of diluent employed, on sperm motility was analysed. Ejaculates from thirteen Holstein bulls were used for sperm kinematic analysis with the ISAS®v1 CASA‐Mot system, using two capillary‐loaded counting chambers (Leja® and Cell‐Vu®) and one drop displacement chamber (Makler®).

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evaluate sperm morphology

Evaluate sperm morphology

How do you do stain to evaluate sperm morphology?

Approximately 15% of couples have infertility problems. Evaluate sperm morphology is an important parameter forsuccessful fertilization. In assisted reproduction techniques (Kuster et al., 2004) the Kruger criteria(1986) and the WHO classification are the most important. According to the Kruger criteria, the head,neck and tail of the sperm must be normal and 70% of the head must be covered by the acrosome.

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espermatozoide

Sperm quality and behavior of subpopulations.

Sperm quality and subpopulations behaviour.

The quality of the sperm from a semen sample does not depend, as was previously thought, on the individual quality of the semen, this depend the joint action of many sperm subpopulations.

espermatozoide
This conclusion, which is based on research carried out in recent decades by various research groups, has been corroborated by the joint work of researchers from the University of Valencia and the PROISER R + D, S.L.

The study on the sperm behaviour and their quality in samples of diverse species has been one of the main objectives of the research group by Dr. Carles Soler in the Departament of Celular biology, Functional Biology and Physical Anthropology of the Universitat de València for several decades. A line of research that has been linked to the approaches of I D I from the Valencian company PROISER, dedicated to the development of solutions for the diagnosis of semen samples. They have developed a revolutionary software to study the divers quantitative parameters of sperm samples.

As a result of the experience acquired, Dr. Carles Soler, as head of the University’s research group and as scientific director of PROISER, was invited to be the editor of two special issues in the prestigious journals Asian Journal of Andrology (2016) and Reproduction, Fertility and Development (2018), respectively, with morphometry and sperm kinetics.

The CASA systems (Computer Assisted Semen Analysis) developed by PROISER provides a databases for tens of thousands of sperm. The application of advanced statistical techniques of multivariate analysis (main components and cluster) from these databases have allowed to consolidate the concept of subpopulations.

Hitherto, has been thought that the behavior of sperm within an ejaculate was comparable to what happens in a marathon: many runners, in principle equivalent, competing for the goal that is the oocyte. Now, the verification mathematically coherent subpopulations points more or less organized team concept.

All of this is around about what happen the sperm in a female tract. Each spermatozoonfind many obstacules and barriers that help to select the best sperm. We can say that it is similar to chess. It would not make sense to spend the towers or even the king in the opening and the first dabbling, that’s what the pawns are for.

espermatozoideIn any case, we still do not know what the rules that the sperm through in the female genital tract. The essay by the Universitat de València and PROISER, are currently work for to find more solutions.

 

Referent in the reproduction area

In addition to the physiological conditions, these results should lead to the definition of changes in the strategies followed in assisted reproduction, both in their veterinary and human applications. This group of studies and the new perspectives that have consider turned the group of the Universitat de València and PROISER into world leaders.

This new points come in addition to other PROISER findings in the same area. It is this private company has been developing software and computer applications for more than a decade that help to do a successful seminal analysis.

In this way, PROISER continues to advance and placing Valencian talent at the top of the international ranking.